MILAN, ITALY – SEPTEMBER 21: Federico Dimarco of Internazionale celebrates with teammate Francesco Pio Esposito after scoring his team’s first goal during the Serie A match between FC Internazionale and US Sassuolo Calcio at Giuseppe Meazza Stadium on September 21, 2025 in Milan, Italy. (Photo by Marco Ruzzani/Getty Images)
Inter will be looking to regain their form against a side of Fiorentina who are in crisis, with Lautaro Martinez and Francesco Pio Esposito playing alongside Moise Kean and Albert Gutmundsson.
The match will kick off at San Siro at 19:45 GMT.
You can follow all the build-up and action from today’s six Serie A matches on our live blog.
The Nerazzurri had won all seven games in all competitions before suffering a sour 3-1 defeat at Napoli, who were still reeling from a controversial penalty decision.
Henrikh Mkhitaryan was injured in the incident and will be out for a month, while Marcus Thuram and Matteo Darmian also remain sidelined.
This means that Petar Susic will be included in the starting XI, with Pio Esposito preferred over Ange Yoan Bony as Lautaro Martínez’s partner.
Fiorentina is in crisis this season, with four draws and four losses in Serie A, without a single win.
They at least responded at the weekend, fighting back from 2-0 down and snatching a point with two penalties in stoppage time.
Keane and Gudmundsson once again led the attack, with former Inter winger Robin Gosens providing support.
Tariq Lamptey and Christian Kouame are both sidelined with knee ligament injuries.
Inter vs Fiorentina lineup
Intel: Summer. Akanji, Bisek, Bastoni. Dumfries, Barella, Calhanoglu, Sučić, Dimarco. Lautaro Martinez, Pio Esposito
Fiorentina: De Gea. Comuzzo, Mari, Viti. Dodo, Soum, Mandragora, Ndur, Gosens. Keene Gudamundson
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